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Association of tumour necrosis factor α promoter polymorphisms with ankylosing spondylitis in Taiwan
  1. Ming-Yuh Shiau1,
  2. Mei-Kuei Lo2,
  3. Cheng-Pei Chang2,
  4. Tzi-Peng Yang3,
  5. Kuo-Ting Ho4,
  6. Yih-Hsin Chang3
  1. 1Hung Kuang University, Taichung, Taiwan, ROC; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC
  2. 2Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Show Chwan Memorial Hospital, Changhwa, Taiwan, ROC
  3. 3School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan, ROC
  4. 4Department of Life Sciences, Chung Hsing University, Taichung, Taiwan, ROC
  1. Correspondence to:
    Dr Yih-Hsin Chang
    School of Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan, Republic of China; cyh{at}csmu.edu.tw

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Ankylosing spondylitis is a genetic-susceptible inflammatory spondyloarthropathy that mainly affects the sacroiliac joints. Tumour necrosis factor (TNF)α, a potent proinflammatory cytokine and immune modulator of joint destruction, is suggested to be a risk factor for the development of ankylosing spondylitis.1 Evidence of an association between TNFα gene polymorphisms and ankylosing spondylitis showed conflicting results. Most of such studies focused on Caucasian subjects; few in the Taiwanese population were documented except for a recent study that reported the association between the interleukin 1 gene cluster and ankylosing spondylitis.2

Our study examined the distribution of TNFα promoter polymorphisms among Taiwanese patients with ankylosing spondylitis. A total of 143 patients with ankylosing spondylitis (97 men and 46 women, mean (standard deviation (SD)) age 41.7 (11.5) years), defined by the modified …

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