Article Text

PDF
Improved insulin sensitivity by anti-TNFα antibody treatment in patients with rheumatic diseases
  1. Frank C Huvers1,
  2. Calin Popa2,
  3. Mihai G Netea3,
  4. Frank H J van den Hoogen4,
  5. Cees J Tack5
  1. 1Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  2. 2Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  3. 3Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  4. 4Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
  5. 5Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  1. Correspondence to:
    Dr C Popa
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, P O Box 9101, Nijmegen 6500 HB, The Netherlands; c.popa{at}aig.umcn.nl

Statistics from Altmetric.com

Insulin resistance is a key factor in the pathogenesis of the metabolic syndrome and type 2 diabetes, but the underlying mechanisms remain poorly understood. Adipocytokines, including tumour necrosis factor α (TNFα), interleukin 6, leptin and adiponectin,1,2 are increasingly recognised as important regulators of both insulin sensitivity, as well as inflammation, and a dysregulation of their levels and/or functions has been shown in both obesity and rheumatoid arthritis.3 Further investigations have substantiated the important negative effects of TNFα on insulin-mediated glucose uptake and the development of insulin resistance.4 In this study, the influence of therapeutic TNFα blockade on insulin sensitivity was investigated in regularly treated patients with rheumatic diseases.

A group of eight patients who were non-diabetic and having various chronic inflammatory disorders (table 1) were investigated in an open prospective …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.