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Factor XII autoantibodies as a novel marker for thrombosis and adverse obstetric history in patients with systemic lupus erythematosus
  1. Maria Laura Bertolaccini1,
  2. Kirti Mepani1,
  3. Giovanni Sanna1,2,
  4. Graham R V Hughes1,
  5. Munther A Khamashta1
  1. 1Lupus Research Unit, The Rayne Institute, King’s College London School of Medicine at Guy’s, King’s and St Thomas’ Hospitals, St Thomas’ Hospital, London, UK
  2. 2Department of Rheumatology, Homerton University Hospital NHS Foundation Trust, London, UK
  1. Correspondence to:
    Dr M L Bertolaccini
    Lupus Research Unit, The Rayne Institute, King’s College London School of Medicine at Guy’s, King’s and St Thomas’ Hospitals, St Thomas’ Hospital, London SE1 7EH, UK; maria.bertolaccini{at}kcl.ac.uk

Abstract

Aim: To investigate the clinical significance of anti-factor XII (FXII) in a large cohort of patients with systemic lupus erythematosus (SLE).

Patients and methods: This study comprised 127 patients with SLE. IgG and IgM anti-FXII were tested by an in-house ELISA. 123 healthy donors comprised the control group.

Results: 51 (40%) patients with SLE and 9 (7%) healthy controls were positive for anti-FXII. IgG and IgM anti-FXII were frequently found in patients with thrombosis (28% and 13%, respectively). Levels of IgG and IgM anti-FXII were higher in patients with thrombosis than in the control group (p<0.001 and p = 0.005, respectively). Anti-FXII was more frequent in patients with arterial thrombosis (31% vs 4% for IgG and 14% vs 3% for IgM, respectively) and venous thrombosis than in controls (37% vs 4% for IgG). IgG anti-FXII were more frequent in patients with miscarriages and fetal death (35% and 40% vs 4% for IgM). The prevalence of IgM anti-FXII was not different between groups.

Conclusion: Anti-FXII are frequent in patients with SLE. Their presence is associated with thrombosis and adverse obstetric history, making these antibodies a novel marker for the antiphospholipid syndrome.

  • aCL, anticardiolipin antibodies
  • aPL, antiphospholipid antibodies
  • aPS–PT, antibodies to phosphatidylserine–prothrombin complex
  • aPT, antiprothrombin antibodies
  • BBS, borate-buffered saline
  • FXII, factor XII
  • LA, lupus anticoagulant
  • SLE, systemic lupus erythematosus

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Footnotes

  • Published Online First 4 October 2006

  • Funding: MLB is funded by the Louise Gergel Fellowship.

  • Competing interests: None declared.

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