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- aPL, antiphoshoipid
- ASaxial, ankylosing spondylitis with only axial involvement
- ASperipheral, ankylosing spondylitis with axial and peripheral arthritis
- ASnegative, ankylosing spondylitis without autoantibodies
- ASpositive, ankylosing spondylitis with autoantibodies
- BASDAI, Bath Ankylosis Spondylitis Disease Activity Index
Infliximab, a monoclonal antibody that targets membrane and soluble tumour necrosis factor (TNF)α, has recently been successfully used to treat patients with active ankylosing spondylitis.1,2 No distinction in terms of axial or peripheral involvement has ever been considered in evaluating the clinical response and autoantibody induction secondary to the infliximab regimen in patients with ankylosing spondylitis.
In this study, we evaluated the effectiveness and tolerability of infliximab in 23 patients with ankylosing spondylitis with only axial involvement (ASaxial) and in 24 patients with ankylosing spondylitis with axial and peripheral arthritis (ASperipheral) (Bath Ankylosis Spondylitis Disease Activity Index (BASDAI) ⩾4),3 and the occurrence of autoantibody induction4–7 in the two different subsets and their clinical relevance in terms of outcome. All patients received infliximab (5 mg/kg) according to …
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