Statistics from Altmetric.com
The collagen type II (CII) 263–272 peptide is a predominant T and B cell antigenic peptide in rheumatoid arthritis.1 Crystallographic data showed that 263F and 264K of CII263–272 are mainly responsible for binding with HLA-DR, and that 267Q and 270K were the major T cell receptor (TCR)-contact residues.2,3 We have shown that the CII altered peptide ligand (APL) with individual or consecutive substitutions of the TCR-contact amino acids could inhibit T cell activation induced by wild-type CII peptide in the context of HLA-DRB1, among which the most potent T cell activation suppressor is sub268–270, in which the amino acids of wild-type CII263–272 at positions 268, 269 and 270 were substituted with glycine or alanine (FKGEQAGAGE, substitutions underlined).4,5 Collagen-induced arthritis (CIA) is induced by wild-type CII in susceptible rodent strains. …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.