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Investigation of association of the DLG5 gene with psoriatic arthritis
  1. Pauline Ho,
  2. Jane Worthington,
  3. Ian N Bruce,
  4. Anne Barton
  1. Arc-Epidemiology Unit, University of Manchester, Manchester, UK
  1. Correspondence to:
    Pauline Ho
    Arc-Epidemiology unit, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK;pauline.ho{at}manchester.ac.uk

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Psoriatic arthritis (PsA) is defined as “an inflammatory arthritis associated with psoriasis which is usually negative for rheumatoid factor” and is the second most common cause of inflammatory joint disease after rheumatoid arthritis.1 A strong genetic component to disease aetiology has been shown, with the sibling recurrence risk (λs) estimated to be 27.2 Patients with Crohn’s disease have an increased risk of developing both PsA and psoriasis.3,4 Crohn’s disease and PsA are also both cytokine driven and both respond to anti-tumour necrosis factor α treatment. We therefore hypothesised that common genetic factors may underlie these two conditions. Indeed, the major Crohn’s disease susceptibility gene, CARD15, has been reported to be associated with PsA in …

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