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A non-major histocompatibility locus determines tissue specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model
  1. Ming-Cai Zhang1,*,
  2. Shiro Mori2,*,
  3. Fumiko Date1,
  4. Hiroshi Furukawa1,
  5. Masao Ono1
  1. 1Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
  2. 2Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, Japan
  1. Correspondence to:
    Dr Masao Ono
    Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, Miyagi 980-8575, Japan; onomasao{at}mail.tains.tohoku.ac.jp

Abstract

Background: The incidence and characteristics of spontaneous ankylosis in the ankle of specific F1 mice descended from two Fas-deficient strains were reported. Here the coincidence of synovial proliferation and ankylosis in the descendent F2 mice is reported.

Aim: To clarify whether the two distinct manifestations are genetically different.

Methods: An arthropathic group of mice (MCF2) were bred by intercrossing MRL/Mp.Faslpr-sap/sap and C3H/He.Faslpr mice. All mice were killed by bleeding under anaesthesia when they were 6 months old. Pathological grades for synovial proliferation were determined by microscopical examination. To obtain a linkage locus, the whole genome of male MCF2 mice was scanned by using 73 microsatellite markers.

Results: Synovial proliferation was equally observed in male and female MCF2 mice. No correlation was observed between the grades of synovial proliferation and the ankylosis occurring in the MCF2 mice. A suggestive susceptibility locus was shown in the middle of chromosome 11. This locus was an MRL allele with a recessive inheritance mode.

Conclusion: The pathogenic mechanisms of synovial proliferation and ankylosis are genetically different. The present locus is overlapped with some loci associated with rheumatoid arthritis and with others associated with experimental arthritides.

  • MCF2, (MRL/rpl×C3H/lpr)F2
  • SAP, signalling lymphocyte activation molecule-associated protein
  • SLAM, signalling lymphocyte activation molecule

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Footnotes

  • * These authors contributed equally to this work.

  • Funding: This study was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan to SM (number 15390607) and MO (number 16390113).

  • Competing interests: None.

  • Published Online First 25 July 2006

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