Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: The Rotterdam Study
- M Reijman1,
- H A P Pols3,
- A P Bergink2,3,
- J M W Hazes4,
- J N Belo5,
- A M Lievense5,
- S M A Bierma-Zeinstra5
- 1Department of Epidemiology and Biostatistics, Rotterdam, The Netherlands
- 2Department of Orthopedics, Erasmus Medical Center, Rotterdam, The Netherlands
- 3Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
- 4Department of Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands
- 5Department of General Practice, Erasmus Medical Center, Rotterdam, The Netherlands
- Correspondence to:
Department of Orthopedics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands;
- Accepted 7 July 2006
- Published Online First 12 July 2006
Objective: To investigate the relationship between body mass index (BMI) and the incidence and progression of radiological knee as well as of radiological hip osteoarthritis.
Design: Cohort study.
Setting: Population based.
Participants: 3585 people aged ⩾55 years were selected from the Rotterdam Study, on the basis of the availability of radiographs of baseline and follow-up.
Main outcome measures: Incidence of knee or hip osteoarthritis was defined as minimally grade 2 at follow-up and grade 0 or 1 at baseline. The progression of osteoarthritis was defined as a decrease in joint space width.
Methods:x Rays of the knee and hip at baseline and follow-up (mean follow-up of 6.6 years) were evaluated. BMI was measured at baseline.
Results: A high BMI (>27 kg/m2) at baseline was associated with incident knee osteoarthritis (odds ratio (OR) 3.3), but not with incident hip osteoarthritis. A high BMI was also associated with progression of knee osteoarthritis (OR 3.2). For the hip, a significant association between progression of osteoarthritis and BMI was not found.
Conclusion: On the basis of these results, we conclude that BMI is associated with the incidence and progression of knee osteoarthritis. Furthermore, it seems that BMI is not associated with the incidence and progression of hip osteoarthritis.
- BMI, body mass index
- JSN, joint space narrowing
- JSW, joint space width
- ROA, radiographic osteoarthritis
Published Online First 12 July 2006
Competing interests: None.
MR and SMAB-Z had the idea for the study. MR and SMAB-Z managed the study. MR, HAPP, AML and SMAB-Z were responsible for the analysis and interpretation of the data. All authors commented on the paper.
Ethical approval: Ethical approval was obtained from the medical ethics committee of the Erasmus Medical Center.