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Tumour necrosis factor receptor 2 (TNFRSF1B) association study in Sjögren’s syndrome
  1. Corinne Miceli-Richard1,*,
  2. Philippe Dieude2,*,
  3. Eric Hachulla4,
  4. Xavier Puechal5,
  5. François Cornelis2,
  6. Xavier Mariette1
  1. 1
    Service de Rhumatologie, Institut Pour la Santé et la Recherche Médicale (INSERM) U802, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris 11, Le Kremlin Bicêtre, France
  2. 2
    GenHotel, Université d’Evry-Paris 7, Evry Genopole, France
  3. 4
    Service de Médecine Interne, Hopital Claude-Huriez, CHU de Lille, Université Lille 2, France
  4. 5
    Service de Rhumatologie, Centre Hospitalier du Mans, Le Mans, France
  1. Corinne Micheli-Richard, Service de Rhumatologie, Institut Pour la Santé et la Recherche Médicale (INSERM) U802, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris 11, Le Kremlin Bicêtre, France; corinne.miceli{at}bct.aphp.fr

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Primary Sjögren’s syndrome (pSS) is a complex disease involving both genetic and environmental factors. Among the genetic susceptibility factors, HLA-DRB1 has been extensively studied as a strong candidate gene and the association of HLA-DRB1*0301 (DR3) with pSS has been frequently reported among Caucasians.1 2 As the Tumour Necrosis Factor α (TNFα) gene is located within the HLA region, its contribution to disease susceptibility has also been studied. We have previously reported a significant association of TNF-308A allele with pSS, in strong linkage disequilibrium with HLA-DRB1*03.3 This association was restricted to patients with anti-SSB antibodies. TNF exerts its action through two cell …

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