Article Text

PDF
Relationship between blood hydroxychloroquine and desethylchloroquine concentrations and cigarette smoking in treated patients with connective tissue diseases
  1. Gaëlle Leroux1,
  2. Nathalie Costedoat-Chalumeau1,
  3. Jean-Sébastien Hulot2,
  4. Zahir Amoura1,
  5. Camille Francès3,
  6. Guy Aymard2,
  7. Philippe Lechat2,
  8. Jean-Charles Piette1
  1. 1
    Université Paris 6, AP-HP, Service de Médecine Interne, Centre de Référence National pour le Lupus Systémique et le Syndrome des Antiphospholipides, Paris, France
  2. 2
    Université Paris 6, AP-HP, Service de Pharmacologie, Centre Hospitalier Universitaire Pitié-Salpêtrière, Université Paris VI Pierre et Marie Curie, Paris, France
  3. 3
    Université Paris 6, AP-HP, Service de Dermatologie-Allergologie, Hôpital Tenon, Paris, France
  1. Nathalie Costedoat-Chalumeau, AP-HP, Service de Médecine Interne, Centre de Référence National pour le Lupus Systémique et le Syndrome des Antiphospholipides, Centre Hospitalier Universitaire Pitié-Salpêtrière, 47–83 Boulevard de l’Hôpital, 75651 Paris Cedex 13, France; nathalie.costedoat{at}psl.aphp.fr

Statistics from Altmetric.com

Cigarette smoking has been suspected to increase the risk and the activity of systemic lupus erythematosus (SLE)1 2 and cutaneous lupus.3 4 Some data indicate that cigarette smoking might interfere with the effectiveness of hydroxychloroquine and chloroquine in cutaneous lupus.3 4 As these antimalarial agents are partly metabolised via the cytochrome P450 enzyme system and as the constituents of cigarette smoke are known potent inducers of cytochrome P450, it has been hypothesised that the resistance of cutaneous lupus might be explained by a modification of the metabolism of these …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.