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Familial Mediterranean fever (FMF) is an autoinflammatory disorder, characterized by periodic fever and serosal inflammation, often complicated by systemic amyloidosis. Maintenance treatment of FMF with colchicine can reduce disease activity and prevent amyloidosis. Some patients, however, fail colchicine therapy. Many reports have recently been published concerning the effective use of a recombinant IL-1 receptor antagonist, anakinra, in several closely related disorders.1–4 These results prompted us to use anakinra in a 14-year-old FMF patient who was unresponsive to colchicine therapy (2 mg/day). A diagnosis of FMF was confirmed by analysis of the MEFV gene (pM694V, M694I).
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