Article Text

PDF
The use of the tumour necrosis factor antagonist infliximab in heart transplant recipients: two case reports
  1. S Metyas1,
  2. D La1,
  3. D G Arkfeld1
  1. 1
    USC, Keck School of Medicine, Los Angeles, California, USA
  1. Professor D G Arkfeld, University of Southern California, Keck School of Medicine, Department of Medicine – Rheumatology, 2011 Zonal Avenue, HMR 711, Los Angeles, CA 90033, USA; arkfeld{at}usc.edu

Statistics from Altmetric.com

Inflammatory cytokines, such as tumour necrosis factor alpha (TNF-α), have been implicated in the pathophysiology of heart failure, leading to the hypothesis that TNF inhibition might improve the symptoms of patients with moderate-to-severe cardiac symptoms. Recent data from the Anti-TNF Therapy Against Congestive Heart failure (ATTACH) pilot study, however, suggested that infliximab, a chimeric monoclonal antibody against TNF-α, not only failed to produce clinical benefits, but given at higher doses (10 mg/kg) was associated with a worsening of cardiac symptoms. Conversely, two large-scale trials, RECOVER and RENAISSANCE, examined the effects of infliximab and etanercept in over 2000 patients with heart failure, finding no …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.