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QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries
  1. Tuulikki Sokka1,
  2. Hannu Kautiainen2,
  3. Sergio Toloza3,
  4. Heidi Mäkinen4,
  5. Suzan M M Verstappen5,
  6. Merete Lund Hetland6,
  7. Antonio Naranjo7,
  8. Eva Baecklund8,
  9. Gertraud Herborn9,
  10. Rolf Rau10,
  11. Massimiliano Cazzato11,
  12. Laure Gossec12,
  13. Vlado Skakic13,
  14. Feride Gogus14,
  15. Stanislaw Sierakowski15,
  16. Barry Bresnihan16,
  17. Peter Taylor17,
  18. Catherine McClinton18,
  19. Theodore Pincus19,
  20. for the QUEST-RA Group
  1. 1
    Jyväskylä Central Hospital, Jyväskylä, and Medcare Oy, Äänekoski, Finland
  2. 2
    Medcare Oy, Äänekoski, Finland
  3. 3
    Hospital San Juan Bautista, Catamarca, Argentina
  4. 4
    Jyväskylä Central Hospital, Jyväskylä, Finland
  5. 5
    University Medical Center Utrecht, Utrecht, The Netherlands
  6. 6
    Copenhagen Univeraity Hospital at Hvidovre, Hvidovre, Denmark
  7. 7
    Hospital de Gran Canaria Dr Negrin, Las Palmas, Spain
  8. 8
    Uppsala University Hospital, Uppsala, Sweden
  9. 9
    Evangelisches Fachkrankenhaus, Ratingen, Germany
  10. 10
    Evangelisches Fachkrankenhaus, Ratingen, Germany
  11. 11
    Ospedale Santa Chiara, Pisa, Italy
  12. 12
    Université René Descartes, Hôpital Cochin, Paris, France
  13. 13
    Rheumatology Institut, Niska Banja, Serbia
  14. 14
    Gazi Medical School, Ankara, Turkey
  15. 15
    Medical University in Bialystok, Bialystok, Poland
  16. 16
    St. Vincent University Hospital, Dublin, Ireland
  17. 17
    Charing Cross Hospital, London, UK
  18. 18
    Charing Cross Hospital, London, UK
  19. 19
    NYU Hospital for Joint Diseases, New York, NY, USA
  1. Tuulikki Sokka, Arkisto/Tutkijat, Jyvaskyla Central Hospital, 40620 Jyvaskyla, Finland; tuulikki.sokka{at}ksshp.fi

Abstract

Objective: To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA.

Methods: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease and treatment-related variables were collected and analysed using descriptive statistics. Variation in disease activity on DAS28 (disease activity score on 28-joint count) within and between countries was graphically analysed. A median regression model was applied to analyse differences in disease activity between countries.

Results: Between January 2005 and October 2006, the QUEST-RA (Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) project included 4363 patients from 48 sites in 15 countries; 78% were female, >90% Caucasian, mean age was 57 years and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but three countries. Overall, patients had an active disease with a median DAS28 of 4.0, with a significant variation between countries (p<0.001). Among 42 sites with >50 patients included, low disease activity of DAS28 ⩽3.2 was found in the majority of patients in seven sites in five countries; in eight sites in five other countries, >50% of patients had high disease activity of DAS28 >5.1.

Conclusions: This international multicentre cross-sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005–6 including countries that are infrequently involved in clinical research projects.

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Footnotes

  • Competing interests: None declared.

  • Abbreviations:
    BMI
    body mass index
    DAS28
    disease activity score on 28-joint count
    DMARD
    disease-modifying antirheumatic drug
    ESR
    erythrocyte sedimentation rate
    HAQ
    Health Assessment Questionnaire
    QUEST-RA
    Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis
    RA
    rheumatoid arthritis
    RF
    rheumatoid factor

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