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Cellular targets of interleukin-18 in rheumatoid arthritis
  1. Sheng-Ming Dai1,
  2. Zheng-Zheng Shan1,
  3. Huji Xu2,
  4. Kusuki Nishioka3
  1. 1
    Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China
  2. 2
    Department of Rheumatology and Immunology, Changzheng Hospital, Second Military Medical University, Shanghai, China
  3. 3
    Department of Bioregulation, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan
  1. Dr Sheng-Ming Dai, Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, P R China; dsm{at}medmail.com.cn

Abstract

Recent data are presented which indicate a critical role for interleukin (IL)-18 in rheumatoid arthritis (RA). The T cells and macrophages invading the synovium or in the synovial fluid are the chief cellular targets of IL-18 in RA. Neutrophils, dendritic cells and endothelial cells may also be cellular mediators of IL-18. The direct effect of IL-18 on fibroblast-like synoviocytes or chondrocytes may not be essential or important. In RA, IL-18, which is mainly produced by macrophages, activates T cells and macrophages to produce proinflammatory cytokines, chemokines, adhesion molecules and RANKL which, in turn, perpetuate chronic inflammation and induce bone and cartilage destruction.

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Footnotes

  • Competing interests: None declared.

  • This study was supported in part by grants from National Natural Science Foundation of China (No. 30672112) and Shanghai Pujiang Talent Program (No. 06PJ14121).

  • Abbreviations:
    CIA
    collagen induced arthritis
    DC
    dendritic cell
    GM-CSF
    granulocyte-macrophage colony stimulating factor
    ICAM-1
    intercellular adhesion molecule-1
    IFNγ
    interferon γ
    IL
    interleukin
    IL-18BP
    IL-18 binding protein
    IL-18R
    IL-18 receptor
    MCP-1
    monocyte chemotactic protein-1
    MIP-1α
    macrophage inflammatory protein-1α
    MMP
    metalloproteinase
    NK
    natural killer
    OA
    osteoarthritis
    RA
    rheumatoid arthritis
    RANKL, receptor activator of NFκB ligand; SCW
    streptococcal cell wall
    TLR
    Toll-like receptor
    TNF
    tumour necrosis factor
    VCAM-1
    vascular cell adhesion molecule-1

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