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Obestatin is a 23 amino acid amidated peptide identified as the product of posttranslational cleavage of the preproghrelin,1 the polypeptide precursor of ghrelin. Obestatin has been reported to have actions opposite to ghrelin,2 but its ghrelin antagonist properties are still unclear and controversial. As our group has identified ghrelin as a peptide synthesised and secreted by chondrocytes, with significant biological activity on cartilage cell metabolism,3 it was conceivable that obestatin might exert some physiological action on chondrocytes. These cells are emerging as a local producer and target of several endocrine factors including ghrelin3 and leptin.4 5 It is of note that the obestatin co-joined hormone ghrelin has been revealed as a convergent factor between bone metabolism and energy homeostases.6 7 So, it was plausible to verify the …
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