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Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis
  1. Antoine W T van Lieshout1,
  2. Jaap Fransen1,
  3. Marcel Flendrie1,
  4. Agnes M M Eijsbouts2,
  5. Frank H J van den Hoogen1,2,
  6. Piet L C M van Riel1,
  7. Timothy R D J Radstake1
  1. 1
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
  2. 2
    St. Maartenskliniek, The Netherlands
  1. Dr T R D J Radstake, MD, Ph.D., Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands, Geert Grooteplein 8, PO Box 9101, 6500 HB Nijmegen, The Netherlands; t.radstake{at}reuma.umcn.nl

Abstract

Background: Antigen-presenting cells (APC) and T cells are considered to play a significant role in the pathogenesis of rheumatoid arthritis (RA). CCL18 and CXCL16 are two chemokines that facilitate T cell attraction by APC, of which a role in the pathogenesis of RA has been suggested.

Objective: To compare the circulating levels of CXCL16 and CCL18 in RA with controls and to investigate the relation of CXCL16 and CCL18 with RA disease activity and joint damage.

Methods: Circulating CCL18 and CXCL16 levels were determined in 61 RA patients with a follow-up of 6 years and a group of 41 healthy controls with ELISA. Chemokine levels were correlated with demographic data, disease activity (DAS28) and joint damage (modified Sharp score). In addition, serum CCL18 and CXCL16 levels from a cohort of 44 RA patients treated with anti-TNF-α were correlated with disease activity.

Results: CCL18 levels in serum were significantly elevated in RA patients compared with controls, while serum CXCL16 levels were not. In contrast to CXCL16, serum CCL18 was positively correlated with disease activity. Both CCL18 and CXCL16 levels decreased upon treatment with anti-TNF-α. Neither CCL18 nor CXCL16 correlated with joint damage and progression.

Conclusion: Here, we show, for the first time, that circulating CCL18 and not CXCL16 levels are elevated in RA patients as compared with controls and correlate with disease activity in RA. More knowledge regarding the regulation and function of both CCL18 and CXCL16 is essential to value their role in RA.

  • CCL18
  • CXCL16
  • disease activity score (DAS-28)
  • rheumatoid arthritis (RA)
  • TNF-α neutralisation

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Footnotes

  • Competing interests: All authors declare they have no conflicts of interest regarding this study

  • Abbreviations:
    APC
    antigen-presenting cells
    CK
    chemokines
    DC
    dendritic cells
    DMARD
    disease-modifying antirheumatic drugs
    RA
    rheumatoid arthritis

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