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Soluble fractalkine in the cerebrospinal fluid of patients with neuropsychiatric lupus
  1. E Sato1,
  2. N Iikuni1,
  3. T Yoshio2,
  4. S Minota2,
  5. N Kamatani1,
  6. H Okamoto1
  1. 1Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
  2. 2Division of Rheumatology and Clinical Immunology, Jichi Medical School, Tochigi, Japan
  1. Correspondence to:
    H Okamoto
    Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku, Tokyo 162-0054, Japan; hokamoto{at}ior.twmu.ac.jp

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Proinflammatory cytokines increase in concentration in the cerebrospinal fluid (CSF) of patients with neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE), and some reports have shown that cytokines are elevated intrathecally.1–3 Recently, levels of Th1 chemokines, monocyte chemotactic protein 1 (MCP-1; CCL2) and interferon inducible protein-10 (IP-10; CXCL10) have been reported to be raised in the CSF of patients with NPSLE, implicating important roles for these chemokines in the pathogenesis of NPSLE.4,5 Here we study the role of soluble fractalkine (CX3CL1) in NPSLE.

A total of 165 patients (161 women and 4 men, aged 16–58 years; mean age 32.4 years) fulfilling the criteria of the American College of Rheumatology for systemic lupus erythematosus (SLE) classification were selected. NPSLE was diagnosed under the American College of Rheumatology criteria for neuropsychiatric lupus syndromes.1 In all, 84 patients were diagnosed with NPSLE and 81 patients did not fulfill our criteria …

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