Article Text

PDF
Examining the exhaled levels of hydrogen peroxide in rheumatoid arthritis: a pilot study
  1. T R Mikuls,
  2. J R O’Dell,
  3. R Ertl,
  4. D A Bergman,
  5. S I Rennard
  1. University of Nebraska Medical Center, Omaha, Nebraska, USA
  1. Correspondence to:
    T R Mikuls
    983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA; tmikuls{at}unmc.edu

Statistics from Altmetric.com

Previous studies have assessed airway inflammation in rheumatoid arthritis by using bronchoalveolar lavage (BAL).1,2 To widen the scope of the study, a biomarker that is less invasive and less expensive is necessary. Recent studies have shown that exhaled breath condensate (EBC), a measure that is minimally invasive and substantially less expensive than BAL, can be used to assess inflammation in the lower respiratory tract.3,4 To assess the utility of this measure, we compared the levels of EBC hydrogen peroxide (H2O2) in patients with rheumatoid arthritis with values in controls.

Patients with rheumatoid arthritis (n = 22) meeting the disease classification criteria5 and controls (n = 23) were studied. As smoking influences EBC measures of inflammation,6 we assessed smoking status (current smoker v non-smoker), excluding subjects self-reporting a diagnosis of chronic …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.