Article Text

PDF
Resolution of sclerodermatous myocarditis after autologous stem cell transplantation
  1. M Al-mashaleh1,
  2. H Bak1,
  3. J Moore2,
  4. N Manolios1,
  5. H Englert1
  1. 1Rheumatology Department, Westmead Hospital, Sydney, Australia
  2. 2Haematology Department, St Vincent’s Hospital, Sydney
  1. Correspondence to:
    H Englert
    Rheumatology Department, Westmead Hospital, PO Box 533, Wentworthville, Sydney, NSW 2165, Australia; manal_mashaleh{at}yahoo.com

Statistics from Altmetric.com

Cardiac involvement in scleroderma is often subclinical1–3 and occurs early in the disease.4,5 The myocardium, pericardium and conduction system may be affected, resulting in heart failure or arrhythmia.6 Symptomatic pericarditis occurs in 7–20% of patients, whereas histological involvement has been reported to be as high as 70–80% at autopsy.6

We believe this is the first report of a man with symptomatic sclerodermatous myocarditis in whom the myocarditis resolved after initial pulse cyclophosphamide treatment followed by autologous stem cell transplantation (ASCT).

A 37-year-old mining electrician developed Raynaud’s syndrome, skin thickening and polyarthritis in September 2003. Scleroderma was diagnosed 4 months later. By July 2004, he noted a 22 kg weight loss, night sweats, heartburn, nausea, …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.