Article Text

PDF
Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population
  1. J Wipff1,
  2. Y Allanore2,
  3. A Kahan1,
  4. O Meyer3,
  5. L Mouthon4,
  6. L Guillevin4,
  7. C Pierlot5,
  8. E Glikmans5,
  9. T Bardin6,
  10. C Boileau2,
  11. F Cornélis5,
  12. P Dieudé5
  1. 1Rheumatology A Department, Paris 5 Descartes University, Cochin Hospital, Paris, France
  2. 2INSERM U781, Paris S Descartes University, Necker Hospital, Paris
  3. 3Rheumatology Department, Paris 12 University, Bichat Hospital, Paris
  4. 4Internal Medicine Department, Paris 5 Descartes University, Cochin Hospital, Paris
  5. 5GenHotel-EA3886, Evry-Genopole, University Evry-Paris 7 Medical School, Paris
  6. 6Fédération de Rheumatologie—Centre Viggo Petersen, Lariboisiere Hospital, AP-HP, Paris
  1. Correspondence to:
    Y Allanore
    Service de Rhumatologie A, hôpital Cochin, 27 rue du faubourg St Jacques, 75014 Paris, France;yannick.allanore{at}cch.ap-hop-paris.fr

Abstract

The minor allele of the R620W missense single-nucleotide polymorphism (SNP; rs2476601) in the PTPN22 (protein tyrosine phosphatase non-receptor 22) gene has been reported to be associated with multiple autoimmune diseases, including type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, autoimmune thyroiditis and vitiligo. Systemic sclerosis (SSc) is a connective tissue disease with some autoimmune abnormalities. The aim of our study was to test for association of the PTPN22*620W allele with SSc in a French Caucasian cohort with a case–control study of 121 patients with SSc and 103 controls. All patients and controls were genotyped for the PTPN22*R620W SNP. No association was found between the PTPN22*620W allele and SSc (7% v 9.2%, p = 0.39). The frequency of genotypes carrying at least one 620W allele was similar in both groups (13% v 17%, p =  0.38). The PTPN22*620W allele was also not associated with autoantibody patterns. Thus, the PTPN22*R620W polymorphism cannot be regarded as a genetic susceptibility factor for SSc in the French Caucasian population.

  • Csk, intracellular tyrosine kinase
  • PTPN22, protein tyrosine phosphatase non-receptor 22 gene
  • SNP, single-nucleotide polymorphism
  • SSc, systemic sclerosis

Statistics from Altmetric.com

Footnotes

  • Published Online First 7 February 2006

  • Funding: This study was supported by Association des Sclérodermiques de France, Association Française des Polyarthritiques, Association Rhumatisme et Travail, Association Polyarctique.

  • Competing interests: None declared.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.