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Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand
  1. J L Min1,
  2. I Meulenbelt1,
  3. N Riyazi2,
  4. M Kloppenburg2,
  5. J J Houwing-Duistermaat3,
  6. A B Seymour4,
  7. C M van Duijn5,
  8. P E Slagboom1
  1. 1Molecular Epidemiology, Leiden University Medical Centre (LUMC), Leiden, Netherlands
  2. 2Rheumatology, LUMC, Leiden
  3. 3Medical Statistics, LUMC, Leiden
  4. 4Discovery Pharmacogenomics, Pfizer Global Research & Development, Groton, USA
  5. 5Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, Netherlands
  1. Correspondence to:
    Josine Min
    Leiden University Medical Centre, Section of Molecular Epidemiology, Wassenaarseweg 72, 2333 AL Leiden, Netherlands; j.min{at}lumc.nl

Abstract

Background: Seven polymorphisms in the matrilin-3(MATN3) gene were previously tested for genetic association with hand osteoarthritis in an Icelandic cohort. One of the variants, involving a conserved amino acid substitution (T303M; SNP5), was related to idiopathic hand osteoarthritis.

Objectives: To investigate SNP5 and two other promising polymorphisms (rs2242190; SNP3, rs8176070; SNP6) for association with radiographic and symptomatic hand osteoarthritis phenotypes, as well as other heritable phenotypes.

Methods: Polymorphisms were examined in two distinct cohorts of subjects: a population based sample from the Rotterdam study (n = 809), and affected siblings from the genetics, osteoarthrosis and progression (GARP) study (n = 382).

Results: The originally described association of T303M with the hand osteoarthritis phenotype was not observed in the populations studied. In the Rotterdam sample, however, carrying the T allele of T303M conferred an odds ratio of 2.9 (95% confidence interval (CI), 1.2 to 7.3; p = 0.02) for spinal disc degeneration. In the GARP study, carriers of the A allele of SNP6 had an odds ratio of 2.0 (95% CI, 1.3 to 3.1, p = 0.004) for osteoarthritis of the first carpometacarpal joint (CMC1) as compared with the Rotterdam sample as a control group. Subsequent haplotype analysis showed that a common haplotype, containing the risk allele of SNP6, conferred a significant risk in sibling pairs with CMC1 osteoarthritis (odds ratio = 1.7 (95% CI, 1.1 to 2.7, p = 0.02)).

Conclusions: These associations suggest that the MATN3 region also determines susceptibility to spinal disc degeneration and CMC1 osteoarthritis.

  • ACR, American College of Rheumatology
  • CMC1, first carpometacarpal joint
  • DIP, distal interphalangeal joint
  • GARP, Genetics, Osteoarthrosis and Progression study
  • htSNP, haplotype tag SNP
  • HWE, Hardy–Weinberg equilibrium
  • ROA, radiographic osteoarthritis
  • SNP, single nucleotide polymorphism
  • osteoarthritis
  • matrilin-3

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Footnotes

  • Published Online First 5 January 2006

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