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Characterisation of Th1/Th2 type, glucose-6-phosphate isomerase reactive T cells in the generation of rheumatoid arthritis
  1. Y Kori1,
  2. I Matsumoto1,2,
  3. H Zhang1,2,
  4. T Yasukochi1,2,
  5. T Hayashi1,
  6. K Iwanami1,
  7. D Goto1,
  8. S Ito1,
  9. A Tsutsumi1,
  10. T Sumida1
  1. 1Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
  2. 2PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama, Japan
  1. Correspondence to:
    Dr I Matsumoto
    Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan; ismatsu{at}md.tsukuba.ac.jp

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Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterised by an unknown inflammatory process in multiple joints. The K/BxN T cell receptor transgenic mouse model is a striking model of inflammatory arthritis characterised by arthritic manifestations similar to those of RA.1 Matsumoto et al reported that arthritis could be provoked by linked T and B cell recognition of a ubiquitously expressed self antigen glucose-6-phosphate isomerase (GPI).2 Recently, immunisation with recombinant human GPI was reported to induce T cell dependent arthritis in DBA/1 mice,3 supporting the notion that GPI reactive T cells have a crucial role in the induction of arthritis.

In our previous study we reported the presence of high titres of anti-GPI antibodies (Abs) in some patients with RA, although a few control subjects were also positive.4 To examine the role of GPI-specific T cells in …

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