Article Text

PDF
Prevalence of an abnormal ankle-brachial index in patients with antiphospholipid syndrome with pregnancy loss but without thrombosis: a controlled study
  1. C Christodoulou,
  2. M Zain,
  3. M L Bertolaccini,
  4. S Sangle,
  5. M A Khamashta,
  6. G R V Hughes,
  7. D P D’Cruz
  1. The Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK
  1. Correspondence to:
    Dr D P D’Cruz
    The Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, SE1 7EH, UK; david.d’cruz{at}kcl.ac.uk

Statistics from Altmetric.com

The antiphospholipid syndrome (APS) is characterised by recurrent arterial or venous thromboembolism, or pregnancy loss, in association with antiphospholipid antibodies.1 The pathogenesis of the obstetric complications remains unclear—both antiphospholipid antibodies and atherosclerosis may have a role. The ankle-brachial index (ABI) is a bedside test which reliably identifies lower extremity peripheral artery disease in asymptomatic people.2 Our hypothesis was that a diffuse vessel wall abnormality as detected by the ABI might be associated with the pregnancy morbidity in patients with APS. We studied patients with APS with previous pregnancy loss but no thrombosis and compared their ABI and vascular risk factors with those of healthy women. The study was approved by the ethics committee.

An 8 …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.