Article Text

PDF
Hypertrophic osteoarthropathy associated with gastrointestinal stromal tumour
  1. L Silva1,
  2. J L Andreu1,
  3. P Muñoz1,
  4. C Isasi1,
  5. A López2
  1. 1Rheumatology Unit, Hospital Universitario Puerta de Hierro, c/San Martín de Porres 4, 28035 Madrid, Spain
  2. 2Department of Pathology, Hospital Universitario Puerta de Hierro, c/San Martín de Porres 4, 28035 Madrid, Spain
  1. Correspondence to:
    Dr J L Andreu
    jlandreu{at}arrakis.es

Statistics from Altmetric.com

Hypertrophic osteoarthropathy (HOA) is a condition characterised by digital clubbing, polyarthralgias, periostosis, occasionally arthritis,1,2 and cutaneous signs of autonomic disorders (sweating, flushing, blanching).3 HOA is classified as either primary (hereditary or occasionally idiopathic in adults) or secondary (often associated with neoplastic or infectious diseases).4 In the industrialised world, 90% of cases are associated with an underlying malignancy, usually a pulmonary neoplasm,1 but also cardiovascular and gastrointestinal diseases.4 Here, we describe the case of a patient presenting with HOA as the first manifestation of a gastrointestinal stromal tumour (GIST).

A 47 year old white man consulted the rheumatologist in January 2005 with a 2 month history of fatigue and bilateral ankle and knee arthritis. Physical examination was normal, except for arthritis in knees and ankles. Blood and urine routine …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.