Background: C reactive protein (CRP) is a known indicator of inflammation. Serum CRP is often raised in patients with inflammatory conditions.
Objective: To determine whether individuals make antibodies to CRP and whether this might affect serum CRP concentrations. Methods: An enzyme linked immunosorbent assay was developed for the detection of antibodies to CRP. Specificity of the reaction was determined by inhibition of the reaction.
Results: Sera from 413 patients were tested and 25 were found to be positive, particularly in patients with rheumatic diseases. Levels of anti-CRP did not correlate with serum CRP levels.
Conclusions: The presence of low CRP levels may not reflect the presence of antibodies to CRP.
- CRP, C reactive protein
- SAA, serum amyloid A
- C reactive protein
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Published Online First 21 September 2005
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