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Antibodies to α-fodrin derived peptide in Sjögren’s syndrome
  1. J He,
  2. Q L Chen,
  3. Z G Li
  1. Department of Rheumatology and Immunology, People’s Hospital, Peking University, 11 Xizhimen South St, Beijing 100044, China
  1. Correspondence to:
    Dr Z G Li
    hejing_1105{at}yahoo.com

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Sjögren’s syndrome (SS) is a chronic autoimmune disorder of unknown cause. Haneji et al identified a 120 kDa fragment of the ubiquitous cytoskeletal protein α-fodrin as an autoantigen in an NFS/sld mouse model of human SS.1 More recently, the sensitivity and specificity of α-fodrin antibodies in SS in several studies suggested that it might be of value in the diagnosis of SS.1–3 In the present study, a conserved motif, rather than the whole protein, in α-fodrin was used as antigenic peptide to define further the role of anti-α-fodrin antibodies in SS. This is the first study so far to evaluate the prevalence of anti-α-fodrin peptide antibodies (α-FPA) in a cohort of Chinese patients with SS.

Serum samples from 89 patients with SS (85 female, 4 male; 74 with primary SS (pSS) and 15 with …

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