Clinical and radiological damage in psoriatic arthritis
- 1MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
- 2Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
- 3Psoriatic Arthritis Program, Centre for Prognosis Studies in The Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
- Correspondence to:
Dr Dafna Gladman
Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 1E–410B, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8;
- Accepted 15 August 2005
- Published Online First 26 August 2005
Background: Psoriatic arthritis may progress to joint damage. Joint damage may be assessed clinically, by identifying deformed, fused, or flail joints, or radiologically, by recording erosions, joint space narrowing, ankylosis, lysis, or surgery. The relation between clinical and radiological damage is unclear.
Objective: To study the ordering of clinical and radiological damage detection, and the clinical features associated with the type of damage detected first.
Methods: The University of Toronto psoriatic arthritis database was used to relate clinical and radiological damage in the hand joints in 655 patients followed prospectively between 1978 and 2003. Generalised estimating equations were used to fit logistic regression models to identify factors that predict classification of damage by radiographic assessment first.
Results: The majority of the joints were not informative, as they either had evidence of damage by both methods at entry, or remained undamaged. Of the remainder, 81% of the joints showed radiological damage first and 19% had clinical damage first. Development of radiological damage first was related to previous detection of swollen joints, and was inversely related to duration of arthritis.
Conclusions: Radiological damage is often detected before clinical damage is observed. Clinical inflammation often precedes the detection of radiological damage.
Published Online First 26 August 2005