Article Text

PDF
Human parvovirus B19 viraemia is associated with neither IgM positivity nor anaemia in patients with rheumatic diseases
  1. Y Munakata,
  2. T Saito
  1. Department of Rheumatology and Haematology, Tohoku University Graduate School of Medicine, Sendai, Japan
  1. Correspondence to:
    Dr Y Munakata
    Department of Rheumatology and Haematology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan; mnkt{at}mail.tains.tohoku.ac.jp

Statistics from Altmetric.com

Human parvovirus B19 (B19) is an erythrovirus and causes anaemia. B19 infection results in not only anaemia but also a variety of symptoms resembling autoimmune diseases.1–3 As B19 is detectable in non-erythroid cells in vivo,4,5 B19 infection is of interest for an understanding of the pathogenesis of autoimmune diseases. We investigated the mode of B19 infection in the bone marrow of patients with rheumatic diseases who had B19 viraemia.

A polymerase chain reaction (PCR) was carried out on peripheral blood samples obtained from 92 febrile adult patients with rheumatic disease in our clinic during 1999–2001 to detect B19 DNA (B19 viraemia); an enzyme linked immunosorbent assay (ELISA) was carried out on serum samples from the patients to detect anti-B19 IgM. Informed consent was obtained from …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.