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Correlation of oestrogen receptor gene polymorphism with gouty arthritis
  1. C-M Huang1,
  2. S-F Lo2,
  3. H-C Lin3,
  4. M-L Chen4,
  5. C-H Tsai5,
  6. F-J Tsai6
  1. 1Department of Internal Medicine, Division of Immunology and Rheumatology, China Medical University Hospital, Taichung, Taiwan
  2. 2Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan
  3. 3School of Physical Therapy, College of Medicine, China Medical University, Taichung, Taiwan
  4. 4Medical Genetics, China Medical University Hospital, Taichung, Taiwan
  5. 5Asia University, Taichung, Taiwan
  6. 6Medical Genetics, China Medical University Hospital, Taichung, Taiwan
  1. Correspondence to:
    F-J Tsai
    Department of Medical Genetics, China Medical University Hospital, No 2 Yuh Der Road, Taichung, Taiwan;d0704@www.cmuh.org.tw

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Gout represents a group of diseases characterised by hyperuricaemia, arthritis, and uric acid crystal formation. Men have a higher level of serum uric acid and are more susceptible to gout than women. The lower serum urate values in women of reproductive age compared with their male counterparts have been ascribed to lower renal postsecretory uric acid reabsorption.1 An increase in ratios of testosterone to oestradiol has been reported to be associated with hyperuricaemia.2

The oestrogen receptor gene is located at chromosome 6q25.1 and has a thymine–adenine (TA) dinucleotide repeat polymorphism 1174 bp upstream from exon 1. This polymorphism has been shown to be associated with menopausal …

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