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Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis
  1. P-T Yang1,
  2. H Kasai2,
  3. W-G Xiao1,
  4. L-J Zhao1,
  5. L-M He2,
  6. A Yamashita2,
  7. X-W Deng2,
  8. M Ito2
  1. 1Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, People’s Republic of China
  2. 2Department of Microbiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi, Japan
  1. Correspondence to:
    P-T Yang
    Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang 110001, People’s Republic of China;yangpingting{at}yahoo.com

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Increasing evidence suggest that macrophage colony-stimulating factor (M-CSF) plays a part in rheumatoid arthritis, but few studies have focused on its role in ankylosing spondylitis. This study aimed at investigating M-CSF expression and its clinical significance in active ankylosing spondylitis and rheumatoid arthritis.

Sandwich ELISA was used to measure serum M-CSF levels in 12 active patients with ankylosing spondylitis (Bath Ankylosing Spondylitis Disease Activity Index of ⩾3)1 and 12 active patients with rheumatoid arthritis.2 Eleven serum samples of healthy volunteers were examined as controls. We also examined M-CSF mRNA expression in peripheral blood mononuclear cells (PBMCs) using real-time reverse transcription-polymerase chain reaction. The relative fold increase in M-CSF mRNA expression in patient groups was determined by 2−ΔΔC.3 Considering that tumour necrosis factor (TNF) α and interleukin (IL) 1α have the ability to induce M-CSF,4 we also investigated their levels and correlations with M-CSF. …

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