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Increasing evidence suggest that macrophage colony-stimulating factor (M-CSF) plays a part in rheumatoid arthritis, but few studies have focused on its role in ankylosing spondylitis. This study aimed at investigating M-CSF expression and its clinical significance in active ankylosing spondylitis and rheumatoid arthritis.
Sandwich ELISA was used to measure serum M-CSF levels in 12 active patients with ankylosing spondylitis (Bath Ankylosing Spondylitis Disease Activity Index of ⩾3)1 and 12 active patients with rheumatoid arthritis.2 Eleven serum samples of healthy volunteers were examined as controls. We also examined M-CSF mRNA expression in peripheral blood mononuclear cells (PBMCs) using real-time reverse transcription-polymerase chain reaction. The relative fold increase in M-CSF mRNA expression in patient groups was determined by 2−ΔΔC.3 Considering that tumour necrosis factor (TNF) α and interleukin (IL) 1α have the ability to induce M-CSF,4 we also investigated their levels and correlations with M-CSF. …
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