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Standardisation of synovial tissue infiltrate analysis: how far have we come? how much further do we need to go?
  1. M D Smith1,
  2. D Baeten2,
  3. A-K Ulfgren3,
  4. I B McInnes4,
  5. O Fitzgerald5,
  6. B Bresnihan5,
  7. P P Tak6,
  8. D Veale5,
  9. on behalf of the OMERACT synovial special interests group
  1. 1Rheumatology Research Unit, Repatriation General Hospital, Adelaide, South Australia
  2. 2Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
  3. 3Department of Medicine Unit of Rheumatology, Karolinska University Hospital, Stockholm, Sweden
  4. 4Centre for Rheumatic Diseases, University of Glasgow, Glasgow, Scotland
  5. 5Department of Rheumatology, St Vincent’s University Hospital, Dublin, Ireland
  6. 6Division of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, The Netherlands
  1. Correspondence to:
    Dr M D Smith
    Rheumatology Research Unit, Repatriation General Hospital, Adelaide, South Australia 5041, Australia; malcolm.smith{at}rgh.sa.gov.au

Abstract

Changes in cellular infiltrate and expression of cytokines, chemokines, and cell adhesion molecules as a result of therapeutic interventions in rheumatoid arthritis can be demonstrated in the synovial membrane. However, before synovial tissue analysis can be used as an outcome measure in such studies, standardisation of the site and method of synovial tissue acquisition, methods of tissue processing, and appropriate methods of detection and measurement of cell lineage specific markers and relevant biological proteins is needed.

  • CP-J, cartilage-pannus junction
  • DIA, digital image analysis
  • DMARD, disease modifying antirheumatic drug
  • IL, interleukin
  • MC, manual counting
  • MCP, metacarpophalangeal
  • OA, osteoarthritis
  • OMERACT, Outcome Measures in Rheumatoid Arthritis Clinical Trial
  • RA, rheumatoid arthritis
  • RCT, randomised controlled trial
  • SM, synovial membrane
  • SQA, semiquantitative analysis
  • immunohistochemistry
  • inflammatory arthritis
  • standardisation
  • synovial tissue

https://doi.org/10.1136/ard.2005.036905

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