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Ann Rheum Dis 2005;64:1347-1349 doi:10.1136/ard.2004.033688
  • Concise report

Further evidence that a cartilage-pannus junction synovitis predilection is not a specific feature of rheumatoid arthritis

  1. L A Rhodes1,
  2. P G Conaghan2,
  3. A Radjenovic1,
  4. A J Grainger3,
  5. P Emery2,
  6. D McGonagle2,4
  1. 1Academic Unit of Medical Physics, University of Leeds, Wellcome Wing, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
  2. 2Academic Unit of Musculoskeletal Disease, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
  3. 3Department of Radiology, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
  4. 4Calderdale Royal Hospital, Salterhebble, Halifax HX3 0PW, UK
  1. Correspondence to:
    Professor D McGonagle
    d.g.mcgonagleleeds.ac.uk
  • Accepted 17 February 2005

Abstract

Background: Qualitative differences in synovitis between the cartilage-pannus junction (CPJ) region and the adjoining suprapatellar pouch (SPP) have been reported in rheumatoid arthritis and the spondyloarthropathies.

Objective: To determine if the distribution of synovitis is the same in osteoarthritis (OA) using sensitive measures of inflammation derived from dynamic, contrast enhanced magnetic resonance imaging (DEMRI).

Methods: 20 subjects with established OA of the knee were recruited. Conventional MR images together with the DEMRI measurements were obtained. Areas of synovitis at the CPJ region and at a distant site in the SPP were calculated; differences in CPJ and SPP synovitis were determined using DEMRI parameters: the initial rate of contrast enhancement (IRE) and maximal enhancement (ME).

Results: The area of synovitis was significantly greater adjacent to the CPJ than in the SPP. IRE and ME measures were greater at the CPJ than the SPP.

Conclusions: The magnitude of synovitis at the CPJ is not disease-specific and applies across the spectrum of degenerative disease as well as inflammatory diseases.

Footnotes

  • We, the authors, are not aware of any competing interests.

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