Early T cell activation in the skin from patients with systemic sclerosis
- 1Department of Medicine/Rheumatology, Thessaly University School of Medicine, Larisa, Greece
- 2Elective Study Programme of Medical Biochemistry, Thessaly University School of Medicine, Larisa, Greece
- 3Aristotle University, Thessaloniki, Greece
- 4Dermatology Clinic, Thessaly University School of Medicine, Larisa, Greece
- Correspondence to:
Dr L Sakkas
Rheumatology Clinic, Medical School of Thessaly University, 22 Papakyriazi Street, Larisa 41222, Greece;
- Accepted 30 January 2005
Objectives: To determine if T cells in skin lesions in systemic sclerosis (SSc) express the early activation antigen CD69 that participates in cell-cell interactions.
Methods: Skin biopsy specimens from 17 patients with SSc were analysed by immunohistochemistry using the indirect peroxidase method and monoclonal antibodies for CD3 (T cell marker), CD69 (early T cell activation marker), and CD68 (macrophage marker).
Results: Mononuclear cells, containing mostly T cells and macrophages, were increased in SSc skin lesions and were present in perivascular areas. CD69 was expressed in these mononuclear cells. There was no correlation between the number of CD3+, CD69+, or CD68+ cells and the Rodnan skin score or disease duration.
Conclusions: The expression of early T cell activation antigen CD69 in skin lesions suggests that T cells may actively participate in cell-cell contact with fibroblasts to promote fibrosis.