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The diagnosis of rheumatoid arthritis (RA) remains imprecise, particularly early in the course of the disease. Up to now, rheumatoid factor (RF) has been used as a typical marker for RA; however, RF has a low specificity because it also occurs in many inflammatory diseases as well as in healthy people. It has recently been shown that autoantibodies directed toward cyclic citrullinated peptides (anti-CCP) are potentially important serological markers for diagnosis and prognosis in RA.1
The proteolytic pathways associated with cellular interactions also seem to have an important role in joint cartilage destruction of RA. Matrix metalloproteinase-3 (MMP-3) is secreted by fibroblasts and synovial cells,2 and it has been shown to be increased in RA serum, not only in the late stage but also in the early stage of the disease. Therefore, MMP-3 is a useful marker for predicting bone damage in early RA.3
In many early cases of RA, patients will not always fulfil the American …
Footnotes
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This study was approved by the ethics committee of Hokkaido College of Pharmacy.