Table 2
Differential diagnosis of multiorgan thrombotic disorders
| Catastrophic APS | DIC | TMHA | ||
|---|---|---|---|---|
| *In cases of familial thrombocytopenic purpura (TTP), acquired idiopathic TTP, and pregnancy related TTP. | ||||
| ADAMTS-13, von Willebrand factor cleaving protease; APS, antiphospholipid syndrome; DIC, disseminated intravascular coagulation; TMHA, thrombotic microangiopathic haemolytic anaemia. | ||||
| Haemorrhagic manifestations | – | + | ± | |
| Anaemia | ± | ± | + | |
| Schistocytes | ± | ± | ++ | |
| Thrombocytopenia | ++ | ++ | +++ | |
| Prolonged prothrombin time | – | + | – | |
| Prolonged activated partial thromboplastin time | ± | + | – | |
| Fibrinogen degradation products | ± | + | – | |
| Antiphospholipid antibodies | ++ | ± | ± | |
| Plasma ADAMTS-13 activity | Normal? | Moderately reduced | Absent* or severely reduced | |
