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Matters arising
HLA-DR-DQ haplotypes and genotypes in Finnish patients with rheumatoid arthritis
  1. S Harney1,
  2. B P Wordsworth1,
  3. M A Brown1
  1. 1University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, UK
  1. Correspondence to:
    Professor MA Brown
    mbrownwell.ox.ac.uk

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    We read with great interest the paper by Laivoranta-Nyman et al.1 They studied Finnish patients with rheumatoid arthritis (RA) and controls, and suggested that there exist susceptibility, neutral and protective HLA-DR-DQ haplotypes that do not match the predictions of current hypotheses for the mechanism of association of the HLA class II region and RA.

    The analysis performed, however, does not take into account the effect of marked overrepresentation of some HLA-DRB1 alleles among the cases on the relative frequencies of other alleles in the cases and controls. We believe that this is the reason for the unexpected findings. If a relative predispositional effects model is used, which does take this …

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