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Association between interleukin 6 gene polymorphisms and Behçet’s disease in Korean people
  1. H K Chang1,
  2. W C Jang2,
  3. S B Park2,
  4. S M Han2,
  5. Y H Nam2,
  6. S S Lee3,
  7. J U Kim4,
  8. H S Lee5
  1. 1Division of Rheumatology, Department of Internal Medicine, Dankook University, Cheonan, South Korea
  2. 2Department of Chemistry, Dankook University, Cheonan, South Korea
  3. 3Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea
  4. 4Department of Laboratory Medicine, Ulsan University, Kangnung, South Korea
  5. 5Division of Rheumatology, Department of Internal Medicine, Hanyang University, Kuri, South Korea
  1. Correspondence to:
    Associate Professor H K Chang
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, Dankook University, 16-5 Anseo-Dong, Cheonan, Chungcheong Nam Do, 330-715, South Korea; hanks22dankook.ac.kr

https://doi.org/10.1136/ard.2004.024208

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    Interleukin (IL) 6 is an important mediator of inflammatory and immune responses, and IL6 gene polymorphisms are known to play a part in chronic inflammatory and autoimmune disorders.1,2 Increased IL6 plasma levels and enhanced IL6 mRNA expression have been found in patients with active Behçet’s disease.3,4 Therefore, this study aimed at investigating the associations between Behçet’s disease in Korean people and two functional IL6 gene polymorphisms—namely, a single nucleotide polymorphism at −174 (G → C) in the IL6 gene promoter (IL6prom) and a variable number of tandem repeat polymorphisms in the 3′ flanking region of the IL6 gene (IL6vntr): the terms IL6prom and IL6vntr were designated as in a previous study.5

    METHODS AND RESULTS

    The study group included 89 Korean patients with Behçet’s disease (36 men, 53 women; mean (SD) age 39.1 (8.5)), fulfilling the International Study Group criteria,6 and 123 controls (47 men, …

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    Footnotes

    • H K Chang and W C Jang contributed equally to this manuscript.