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Progression of lupus nephritis during treatment with mycophenolate mofetil
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Lupus nephritis (LN) determines the prognosis of systemic lupus erythematosus. The standard treatment for the proliferative forms (focal and diffuse proliferative LN, WHO classes III and IV) is intravenous pulse cyclophosphamide in combination with oral prednisone (Austin scheme).1,2 Recently mycophenolate mofetil (MMF) has been shown to be as effective as standard pulse cyclophosphamide for the induction of remission in proliferative LN (n = 21 in each treatment group). Side effects of MMF were fewer than with pulse cyclophosphamide.3 We …