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Telomerase activity in B and T lymphocytes of patients with systemic lupus erythematosus
  1. W Klapper1,
  2. F Moosig2,
  3. A Sotnikova1,
  4. W Qian1,3,
  5. J O Schröder2,
  6. R Parwaresch1
  1. 1Department of Haematopathology and Lymph Node Registry Kiel, University Kiel Niemannsweg 11, 24105 Kiel, Germany
  2. 2Second Department of Internal Medicine, University Kiel, Chemnitzstr 33, 24107 Kiel, Germany
  3. 3Department of Haematology, First affiliated Hospital of Zhejiang University, Qianchun Road 79, Hangzhou 310003, China
  1. Correspondence to:
    Dr W Klapper
    wklapperpath.uni-kiel.de

Abstract

Objective: To evaluate telomerase activity as a marker of lymphocyte proliferation in systemic lupus erythematosus (SLE).

Methods: CD19+, CD4+, and CD8+ lymphocytes were isolated from the peripheral blood of nine patients with SLE and nine healthy controls by means of magnetic bead-coupled antibodies and tested for telomerase activity with the TRAP assay.

Results: Telomerase activity was significantly increased in CD19+ B cells from patients with SLE. CD4+ and CD8+ T cells from lupus patients displayed increased mean telomerase activity, although the difference from normal controls did not reach statistical significance.

Conclusions: Increased telomerase activity in the B and the T cell lineage might indicate activation and proliferation of these lymphocytes.

  • telomerase
  • telomere
  • systemic lupus erythematosus
  • aging

https://doi.org/10.1136/ard.2003.016022

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