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Spontaneous pregnancy in a woman with lupus and thyroiditis despite imminent premature ovarian failure
  1. D Le Thi Huong1,
  2. A Gompel2,
  3. B Wechsler1,
  4. J-C Piette1
  1. 1Department of Internal Medicine, Groupe Hospitalier Pitié-Salpêtrière, 83 boulevard de l’Hôpital 75651 Paris Cedex 13, France
  2. 2Department of Gynaecology, Hotel-Dieu de Paris, 1 place du Parvis Notre Dame 75004 Paris, France
  1. Correspondence to:
    Dr D Le Thi Huong
    ; du.boutinpsl.ap-hop-paris.fr

https://doi.org/10.1136/ard.2002.003012

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    We report a case of spontaneous pregnancy in a woman with lupus and clinical and hormonal changes suggesting imminent premature ovarian failure (POF).

    CASE REPORT

    A French woman born in 1962 had had Raynaud’s phenomenon, photosensitivity, and subacute cutaneous lupus since the age of 15 years, which was treated with hydroxychloroquine. She underwent abortions for unwanted pregnancies in 1986, 1987, and 1988. Various progestin contraceptives were prescribed but rapidly stopped. In 1990 she presented with giant cell thyroiditis with normal thyroxine, thyroid stimulating hormone 6.1 mU/l (normal 0.1–3.2), and negative antithyroperoxidase and antithyroglobulin antibodies. l-Thyroxine 100 μg daily was started. In August 1992 endometriosis was discovered.

    In February 1997 she complained of polyarthritis and sustained climacteric symptoms. She had regular menses with a short luteal phase. Her mother became menopausal at the age of 50. Follicle stimulating hormone (FSH) was increased (95 U/l) with normal oestradiol and karyotype. She was …

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