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Circadian rhythms in RA
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- Published on: 13 April 2016
- Published on: 13 April 2016Melatonin suppression may not be a promising therapeutic option for the treatment of RAShow More
Dear Editor,
The article, "Circadian Rhythms in RA" postulates a dynamic equilibrium between melatonin and cortisol as at least part of the etiology of rheumatoid arthritis. The authors note that the clinical symptoms of pain and stiffness seem to peak around 5:00 o'clock in the morning and that this coincides with the diurnal rhythms of melatonin and cortisol. Because melatonin enhances inflammatory cytokine and...
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