Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

J Martel-Pelletier; D Lajeunesse; P Reboul; J-P Pelletier

doi:10.1136/ard.62.6.501

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Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

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	Abstract	Full	Pdf
May 2003	164	244	222
Jun 2003	80	317	139
Jul 2003	59	204	124
Aug 2003	67	138	75
Sep 2003	40	139	92
Oct 2003	35	156	53
Nov 2003	35	79	34
Dec 2003	25	38	17
Jan 2004	52	95	32
Feb 2004	21	45	18
Mar 2004	33	63	25
Apr 2004	21	54	19
May 2004	51	71	15
Jun 2004	61	114	52
Jul 2004	52	103	39
Aug 2004	59	124	93
Sep 2004	27	125	66
Oct 2004	42	221	70
Nov 2004	28	208	97
Dec 2004	24	140	53
Jan 2005	44	181	85
Feb 2005	29	187	104
Mar 2005	31	142	67
Apr 2005	19	129	75
May 2005	22	90	48
Jun 2005	28	85	48
Jul 2005	24	84	53
Aug 2005	24	103	56
Sep 2005	23	136	55
Oct 2005	21	92	59
Nov 2005	24	110	43
Dec 2005	20	88	31
Jan 2006	17	87	36
Feb 2006	20	91	36
Mar 2006	29	126	57
Apr 2006	26	96	42
May 2006	18	157	43
Jun 2006	21	64	16
Jul 2006	20	85	26
Aug 2006	21	144	53
Sep 2006	14	125	40
Oct 2006	21	115	46
Nov 2006	25	134	50
Dec 2006	12	101	40
Jan 2007	24	124	44
Feb 2007	24	102	53
Mar 2007	23	122	66
Apr 2007	59	19	21
May 2007	61	16	20
Jun 2007	37	28	19
Jul 2007	37	35	16
Aug 2007	42	27	11
Sep 2007	40	14	11
Oct 2007	38	19	14
Nov 2007	67	15	23
Dec 2007	32	6	9
Jan 2008	48	10	14
Feb 2008	88	19	12
Mar 2008	55	12	11
Apr 2008	43	12	12
May 2008	56	9	9
Jun 2008	47	13	15
Jul 2008	65	9	12
Aug 2008	87	6	8
Sep 2008	63	12	11
Oct 2008	69	10	17
Nov 2008	55	9	9
Dec 2008	62	20	12
Jan 2009	96	14	16
Feb 2009	79	14	10
Mar 2009	109	26	37
Apr 2009	84	16	12
May 2009	64	14	12
Jun 2009	72	12	9
Jul 2009	55	14	5
Aug 2009	58	17	10
Sep 2009	79	9	16
Oct 2009	80	22	7
Nov 2009	94	11	18
Dec 2009	86	13	12
Jan 2010	89	10	13
Feb 2010	72	17	14
Mar 2010	108	19	11
Apr 2010	97	20	8
May 2010	78	17	8
Jun 2010	88	12	12
Jul 2010	71	14	9
Aug 2010	146	53	15
Sep 2010	194	106	13
Oct 2010	241	92	13
Nov 2010	217	89	11
Dec 2010	162	62	7
Jan 2011	205	77	15
Feb 2011	261	70	15
Mar 2011	300	79	27
Apr 2011	220	78	8
May 2011	274	80	4
Jun 2011	299	51	3
Jul 2011	283	54	7
Aug 2011	224	46	6
Sep 2011	321	91	11
Oct 2011	254	110	11
Nov 2011	201	209	28
Dec 2011	79	353	43
Jan 2012	82	408	54
Feb 2012	60	389	33
Mar 2012	75	410	48
Apr 2012	69	393	39
May 2012	71	552	42
Jun 2012	52	522	61
Jul 2012	51	434	54
Aug 2012	73	433	52
Sep 2012	68	592	67
Oct 2012	73	819	68
Nov 2012	95	491	76
Dec 2012	75	206	43
Jan 2013	93	165	45
Feb 2013	84	155	26
Mar 2013	91	163	32
Apr 2013	85	175	47
May 2013	96	184	76
Jun 2013	80	157	43
Jul 2013	55	135	1550
Aug 2013	52	134	33
Sep 2013	64	125	32
Oct 2013	68	165	45
Nov 2013	59	174	41
Dec 2013	56	165	33
Jan 2014	70	186	44
Feb 2014	91	178	39
Mar 2014	53	223	44
Apr 2014	63	186	42
May 2014	46	279	68
Jun 2014	37	211	44
Jul 2014	52	198	44
Aug 2014	33	190	57
Sep 2014	53	202	45
Oct 2014	70	235	30
Nov 2014	61	271	51
Dec 2014	52	330	35
Jan 2015	29	256	34
Feb 2015	44	181	33
Mar 2015	40	209	41
Apr 2015	48	210	37
May 2015	36	238	32
Jun 2015	18	169	26
Jul 2015	43	257	39
Aug 2015	35	189	29
Sep 2015	45	169	29
Oct 2015	15	136	35
Nov 2015	30	153	31
Dec 2015	21	231	18
Jan 2016	21	272	29
Feb 2016	38	184	28
Mar 2016	33	175	44
Apr 2016	44	247	59
May 2016	35	183	25
Jun 2016	30	172	39
Jul 2016	32	143	33
Aug 2016	38	131	24
Sep 2016	34	119	24
Oct 2016	30	189	33
Nov 2016	33	206	28
Dec 2016	23	198	8
Jan 2017	25	222	26
Feb 2017	22	815	28
Mar 2017	28	1525	35
Apr 2017	21	327	35
May 2017	18	302	18
Jun 2017	69	225	30
Jul 2017	135	121	27
Aug 2017	134	108	29
Sep 2017	228	202	29
Oct 2017	335	285	36
Nov 2017	403	359	41
Dec 2017	258	230	33
Jan 2018	338	319	38
Feb 2018	400	348	66
Mar 2018	274	239	41
Apr 2018	90	52	18
May 2018	110	61	23
Jun 2018	336	290	44
Jul 2018	262	240	29
Aug 2018	390	363	29
Sep 2018	417	392	38
Oct 2018	568	532	46
Nov 2018	522	494	50
Dec 2018	496	470	32
Jan 2019	552	522	53
Feb 2019	549	525	49
Mar 2019	593	566	51
Apr 2019	719	691	59
May 2019	810	772	42
Jun 2019	851	825	65
Jul 2019	752	737	56
Aug 2019	562	536	59
Sep 2019	573	550	41
Oct 2019	662	648	60
Nov 2019	640	612	64
Dec 2019	524	508	49
Jan 2020	466	433	38
Feb 2020	463	445	52
Mar 2020	530	506	57
Apr 2020	415	387	52
May 2020	399	378	52
Jun 2020	320	284	45
Jul 2020	245	231	30
Aug 2020	275	267	35
Sep 2020	323	299	47
Oct 2020	356	327	39
Nov 2020	404	369	39
Dec 2020	353	328	60
Jan 2021	369	359	44
Feb 2021	406	382	42
Mar 2021	438	406	24
Apr 2021	723	696	75
May 2021	588	575	44
Jun 2021	394	393	65
Jul 2021	436	436	55
Aug 2021	403	403	38
Sep 2021	470	469	43
Oct 2021	472	452	61
Nov 2021	454	435	66
Dec 2021	446	431	58
Jan 2022	333	316	44
Feb 2022	324	288	56
Mar 2022	340	320	47
Apr 2022	339	325	40
May 2022	332	314	36
Jun 2022	290	276	36
Jul 2022	393	382	58
Aug 2022	374	353	49
Sep 2022	420	393	48
Oct 2022	410	401	49
Nov 2022	430	395	45
Dec 2022	291	277	20
Jan 2023	390	376	39
Feb 2023	411	408	32
Mar 2023	558	538	52
Apr 2023	347	312	37
May 2023	533	514	44
Jun 2023	507	491	51
Jul 2023	396	386	44
Aug 2023	295	263	21
Sep 2023	333	317	51
Oct 2023	406	385	47
Nov 2023	388	373	42
Dec 2023	711	73	9
Jan 2024	213	5	1
Feb 2024	310	3	3
Mar 2024	575	14	5
Total	45857	57143	11046

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