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The presence of autoantibodies against tRNA synthetases is a specific serological feature of a clinically distinct entity of autoimmune myositis. This syndrome is characterised by an association of non-erosive arthritis, Raynaud’s phenomenon, and alveolitis. The most common autoimmune response of this disease is directed against the histidyl-tRNA synthetase Jo-1 and therefore also called the anti-Jo-1 syndrome.1–3 In this report we describe a patient with a unique coincidence of anti-Jo-1 antibodies with other myositis related autoantibodies directed to U1RNP typical for mixed connective tissue disease (MCTD) and proteasome.
In a 36 year old female patient, arthralgia, joint swelling, and fever led to the diagnosis of rheumatoid arthritis in 1998. Initial treatment comprised sulfasalazine and prednisolone. In February 2000, she was admitted to our department with a four month history of myalgia and weakness. Physical examination showed a tetraparesis affecting the proximal and peripheral muscles with an apparent areflexia. Gottron’s sign was positive, …
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