You are here

  • Home
  • Archive
  • Volume 62, Issue 4
  • A unique autoantibody pattern of positive anti-Jo-1, anti-U1RNP, and antiproteasome antibodies in autoimmune myositis as a diagnostic challenge

Article Text

Article menu
Download PDFPDF
Letter
A unique autoantibody pattern of positive anti-Jo-1, anti-U1RNP, and antiproteasome antibodies in autoimmune myositis as a diagnostic challenge
  1. E Feist1,
  2. M-L Schneider2,
  3. M Brychcy1,
  4. T Dörner1,
  5. G-R Burmester1,
  6. F Hiepe1
  1. 1Clinic for Rheumatology and Clinical Immunology, University Hospital Charité, Humboldt University of Berlin, Schumannstr 20/ 21, D-10117 Berlin, Germany
  2. 2Clinic for Gastroenterology, Hepatology and Endocrinology, University Hospital Charité
  1. Correspondence to:
    Dr E Feist;
    eugen.feist{at}charite.de

https://doi.org/10.1136/ard.62.4.370

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    The presence of autoantibodies against tRNA synthetases is a specific serological feature of a clinically distinct entity of autoimmune myositis. This syndrome is characterised by an association of non-erosive arthritis, Raynaud’s phenomenon, and alveolitis. The most common autoimmune response of this disease is directed against the histidyl-tRNA synthetase Jo-1 and therefore also called the anti-Jo-1 syndrome.1–3 In this report we describe a patient with a unique coincidence of anti-Jo-1 antibodies with other myositis related autoantibodies directed to U1RNP typical for mixed connective tissue disease (MCTD) and proteasome.

    CASE REPORT

    In a 36 year old female patient, arthralgia, joint swelling, and fever led to the diagnosis of rheumatoid arthritis in 1998. Initial treatment comprised sulfasalazine and prednisolone. In February 2000, she was admitted to our department with a four month history of myalgia and weakness. Physical examination showed a tetraparesis affecting the proximal and peripheral muscles with an apparent areflexia. Gottron’s sign was positive, …

    View Full Text