Efficacy and safety of the fully human anti-tumour necrosis factor α monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: a 12 week, phase II study

L B A van de Putte; R Rau; F C Breedveld; J R Kalden; M G Malaise; P L C M van Riel; M Schattenkirchner; P Emery; G R Burmester; H Zeidler; H M Moutsopoulos; K Beck; H Kupper

doi:10.1136/ard.2003.009563

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Extended report

Efficacy and safety of the fully human anti-tumour necrosis factor α monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: a 12 week, phase II study

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	Abstract	Full	Pdf
Nov 2003	66	101	90
Dec 2003	79	437	297
Jan 2004	65	136	93
Feb 2004	63	89	84
Mar 2004	53	78	69
Apr 2004	30	41	33
May 2004	61	66	30
Jun 2004	62	69	18
Jul 2004	69	72	29
Aug 2004	61	56	26
Sep 2004	41	45	28
Oct 2004	36	28	16
Nov 2004	32	45	14
Dec 2004	26	43	33
Jan 2005	48	53	51
Feb 2005	21	76	53
Mar 2005	22	64	81
Apr 2005	19	77	48
May 2005	19	67	55
Jun 2005	15	47	47
Jul 2005	20	67	40
Aug 2005	9	67	37
Sep 2005	11	58	37
Oct 2005	42	69	59
Nov 2005	25	71	64
Dec 2005	26	55	46
Jan 2006	14	53	35
Feb 2006	16	56	47
Mar 2006	20	80	57
Apr 2006	16	48	35
May 2006	26	43	56
Jun 2006	14	29	22
Jul 2006	14	36	37
Aug 2006	13	41	36
Sep 2006	14	33	34
Oct 2006	21	44	31
Nov 2006	21	48	42
Dec 2006	17	33	25
Jan 2007	8	54	51
Feb 2007	12	52	47
Mar 2007	18	45	52
Apr 2007	18	10	14
May 2007	10	15	22
Jun 2007	11	13	18
Jul 2007	18	14	28
Aug 2007	14	12	17
Sep 2007	30	22	18
Oct 2007	22	18	27
Nov 2007	18	7	11
Dec 2007	12	5	6
Jan 2008	11	15	18
Feb 2008	18	15	15
Mar 2008	21	9	19
Apr 2008	34	15	23
May 2008	13	10	18
Jun 2008	29	15	17
Jul 2008	28	3	19
Aug 2008	40	12	16
Sep 2008	45	4	13
Oct 2008	27	6	19
Nov 2008	12	3	9
Dec 2008	14	3	4
Jan 2009	14	9	12
Feb 2009	22	9	17
Mar 2009	35	13	20
Apr 2009	15	7	29
May 2009	24	3	20
Jun 2009	16	6	14
Jul 2009	21	14	20
Aug 2009	13	4	9
Sep 2009	14	2	10
Oct 2009	44	5	8
Nov 2009	27	15	15
Dec 2009	24	2	14
Jan 2010	11	5	7
Feb 2010	18	8	10
Mar 2010	25	14	10
Apr 2010	10	12	18
May 2010	10	10	8
Jun 2010	22	14	13
Jul 2010	12	10	10
Aug 2010	18	5	11
Sep 2010	28	11	18
Oct 2010	9	7	10
Nov 2010	21	5	7
Dec 2010	13	2	7
Jan 2011	18	8	11
Feb 2011	16	14	19
Mar 2011	23	17	17
Apr 2011	15	4	7
May 2011	23	20	16
Jun 2011	25	1	2
Jul 2011	48	6	9
Aug 2011	48	9	16
Sep 2011	65	13	18
Oct 2011	58	13	13
Nov 2011	71	25	14
Dec 2011	50	32	13
Jan 2012	62	32	12
Feb 2012	77	19	22
Mar 2012	77	35	20
Apr 2012	88	27	19
May 2012	101	42	29
Jun 2012	95	46	11
Jul 2012	69	35	26
Aug 2012	70	35	20
Sep 2012	90	20	23
Oct 2012	97	45	32
Nov 2012	106	49	25
Dec 2012	91	37	20
Jan 2013	96	54	39
Feb 2013	132	54	37
Mar 2013	80	52	19
Apr 2013	140	18	20
May 2013	94	31	20
Jun 2013	61	41	14
Jul 2013	67	45	26
Aug 2013	70	41	13
Sep 2013	82	36	24
Oct 2013	134	31	21
Nov 2013	80	27	28
Dec 2013	56	14	11
Jan 2014	72	32	20
Feb 2014	84	23	16
Mar 2014	112	37	22
Apr 2014	131	47	28
May 2014	87	33	13
Jun 2014	70	25	19
Jul 2014	50	41	30
Aug 2014	60	26	60
Sep 2014	62	39	25
Oct 2014	66	43	36
Nov 2014	77	20	15
Dec 2014	78	27	17
Jan 2015	60	21	13
Feb 2015	61	37	37
Mar 2015	102	36	18
Apr 2015	80	29	20
May 2015	56	25	24
Jun 2015	46	24	11
Jul 2015	65	30	11
Aug 2015	29	23	14
Sep 2015	90	32	18
Oct 2015	41	25	14
Nov 2015	51	39	15
Dec 2015	35	47	16
Jan 2016	54	38	21
Feb 2016	50	46	16
Mar 2016	55	37	27
Apr 2016	62	31	13
May 2016	54	26	16
Jun 2016	51	47	10
Jul 2016	24	16	8
Aug 2016	42	36	11
Sep 2016	58	25	11
Oct 2016	55	33	20
Nov 2016	67	62	23
Dec 2016	47	29	12
Jan 2017	50	46	18
Feb 2017	17	46	21
Mar 2017	9	50	15
Apr 2017	7	64	18
May 2017	8	62	15
Jun 2017	26	72	19
Jul 2017	151	147	7
Aug 2017	53	54	3
Sep 2017	68	54	17
Oct 2017	78	56	14
Nov 2017	73	45	20
Dec 2017	65	43	12
Jan 2018	84	54	10
Feb 2018	108	76	25
Mar 2018	79	55	11
Apr 2018	51	31	22
May 2018	31	29	3
Jun 2018	54	46	13
Jul 2018	72	68	13
Aug 2018	53	41	10
Sep 2018	109	101	8
Oct 2018	109	103	5
Nov 2018	125	111	11
Dec 2018	108	100	6
Jan 2019	99	88	8
Feb 2019	81	73	5
Mar 2019	144	111	35
Apr 2019	37	25	12
May 2019	24	18	9
Jun 2019	21	11	11
Jul 2019	36	25	11
Aug 2019	29	21	10
Sep 2019	22	17	6
Oct 2019	21	21	7
Nov 2019	32	27	11
Dec 2019	33	30	14
Jan 2020	40	30	14
Feb 2020	33	18	8
Mar 2020	50	34	32
Apr 2020	91	55	25
May 2020	62	43	22
Jun 2020	45	27	14
Jul 2020	36	34	10
Aug 2020	18	16	10
Sep 2020	51	41	16
Oct 2020	47	46	26
Nov 2020	57	37	17
Dec 2020	39	20	11
Jan 2021	33	26	15
Feb 2021	157	148	30
Mar 2021	99	79	77
Apr 2021	59	49	22
May 2021	21	18	19
Jun 2021	17	17	19
Jul 2021	18	18	17
Aug 2021	21	21	22
Sep 2021	28	27	15
Oct 2021	43	29	29
Nov 2021	25	17	21
Dec 2021	27	21	12
Jan 2022	36	30	18
Feb 2022	24	18	15
Mar 2022	76	66	48
Apr 2022	47	34	11
May 2022	38	34	18
Jun 2022	30	25	12
Jul 2022	26	22	7
Aug 2022	47	41	5
Sep 2022	43	41	15
Oct 2022	57	38	12
Nov 2022	35	29	15
Dec 2022	57	40	9
Jan 2023	59	42	8
Feb 2023	55	45	9
Mar 2023	115	59	46
Apr 2023	27	22	16
May 2023	25	22	9
Jun 2023	31	23	9
Jul 2023	23	20	10
Aug 2023	29	27	8
Sep 2023	40	31	9
Oct 2023	60	51	13
Nov 2023	120	115	3
Dec 2023	314	69	1
Jan 2024	92	7	2
Feb 2024	246	8	10
Mar 2024	227	21	12
Total	12298	9277	5447

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