Article Text
Letter
Cigarette smoking, TB, and TNF inhibitors
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Accompanying the tremendous excitement about the introduction of TNF inhibitors into the clinic has been caution about potential adverse events that may be associated with the use of these potent immunomodulators. Increased susceptibility to certain infections, particularly Mycobacterium tuberculosis (TB), has been a particular concern.1 Data from animal studies suggest that TNF has a central role in host defence against TB, in part related to effective granuloma formation.2 For infliximab, 277 cases of …