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Sjögren’s syndrome (SS) is an autoimmune disease characterised by lymphocytic infiltration and glandular tissue dysfunction of exocrine glands such as the salivary and lachrymal glands in genetically susceptible people. Several cytokines, including interleukin 10 (IL10), have been proposed to have a role in the pathogenesis of the disease. Although the major genes involved in susceptibility to SS are within the major histocompatibility complex (MHC) region, several putative non-MHC genetic loci (Ro52,1 IL1,2 IL6,3 Fas/FasL,4 mannose binding lectin,5,6 TAP2,7 and glutathione S-transferase M1 gene8 ) have been proposed as candidate genes. Recently, Hulkkonen et al reported that in Finnish patients the haplotypes formed on the basis of the IL10 gene alleles (at the -1082, -819, and -592 loci) were related to susceptibility to primary SS.9 However, no correlation between extraglandular symptoms …