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Molecular mechanisms of cartilage and bone destruction
Cartilage destruction in rheumatoid arthritis
  1. S Gay,
  2. S Kuchen,
  3. R E Gay,
  4. M Neidhart
  1. WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, Department of Rheumatology, University Hospital, Gloriastrasse 25, CH-8091 Zurich, Switzerland
  1. Correspondence to:
    Steffen.Gay{at}ruz.usz.ch

https://doi.org/10.1136/ard.61.suppl_2.ii87

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    Synovial fibroblasts represent an important source of matrix degrading enzymes mediating joint destruction in rheumatoid arthritis.1 In our search for new pathways for the activation of synovial fibroblasts we have detected endogenous retroviral sequences, like the line 1 element (L1).2

    To study the functional …

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