You are here

Article Text

Article menu
Download PDFPDF
Co-stimulatory molecules
Role of interleukin 15 and interleukin 18 in inflammatory response
  1. F Y Liew1,
  2. I B McInnes2
  1. 1Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, UK
  2. 2The Centre for Rheumatic Disease, University of Glasgow
  1. Correspondence to:
    Dr F Y Liew;
    fyl1h{at}clinmed.gla.ac.uk

Abstract

Interleukin 15 (IL15) and interleukin 18 (IL18) are cytokines produced principally by macrophages during innate immune response and subsequently profoundly influence adaptive immunity. Recent studies have shown that IL15 and IL18 play an influential part in inflammatory response. Here we present recent data mainly from our own laboratories illustrating the importance of IL15 and IL18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis.

  • cytokines
  • interleukin 15
  • interleukin 18
  • inflammation
  • IFNγ, interferon γ
  • IL15, interleukin 15
  • IL18
  • interleukin 18
  • RA, rheumatoid arthritis
  • TNFα, tumour necrosis factor α
  • SF, synovial fluid
  • CIA, collagen induced arthritis

https://doi.org/10.1136/ard.61.suppl_2.ii100

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text