Addition of interleukin 1 (IL1) and IL17 soluble receptors to a tumour necrosis factor α soluble receptor more effectively reduces the production of IL6 and macrophage inhibitory protein-3α and increases that of collagen in an in vitro model of rheumatoid synoviocyte activation

G Chevrel; P Garnero; P Miossec

doi:10.1136/ard.61.8.730

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Concise report

Addition of interleukin 1 (IL1) and IL17 soluble receptors to a tumour necrosis factor α soluble receptor more effectively reduces the production of IL6 and macrophage inhibitory protein-3α and increases that of collagen in an in vitro model of rheumatoid synoviocyte activation

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	Abstract	Full	Pdf
Jul 2002	29	85	27
Aug 2002	9	42	17
Sep 2002	0	32	6
Oct 2002	0	24	11
Nov 2002	4	18	9
Dec 2002	4	18	14
Jan 2003	1	16	9
Feb 2003	2	21	8
Mar 2003	4	17	15
Apr 2003	2	16	4
May 2003	3	14	3
Jun 2003	1	7	1
Jul 2003	11	35	3
Aug 2003	11	10	1
Sep 2003	13	24	7
Oct 2003	13	55	11
Nov 2003	18	11	7
Dec 2003	13	11	8
Jan 2004	15	46	4
Feb 2004	16	18	7
Mar 2004	12	10	3
Apr 2004	17	19	2
May 2004	40	44	4
Jun 2004	43	54	13
Jul 2004	39	42	5
Aug 2004	39	43	6
Sep 2004	28	33	13
Oct 2004	10	18	9
Nov 2004	10	22	11
Dec 2004	7	16	7
Jan 2005	13	20	7
Feb 2005	10	16	6
Mar 2005	12	21	8
Apr 2005	3	16	6
May 2005	5	12	16
Jun 2005	4	23	11
Jul 2005	6	17	4
Aug 2005	4	25	7
Sep 2005	8	5	4
Oct 2005	7	18	7
Nov 2005	7	18	9
Dec 2005	1	7	4
Jan 2006	10	19	7
Feb 2006	3	14	5
Mar 2006	0	10	12
Apr 2006	3	5	3
May 2006	3	9	6
Jun 2006	2	2	1
Jul 2006	5	8	3
Aug 2006	7	7	3
Sep 2006	3	10	4
Oct 2006	1	14	2
Nov 2006	2	21	12
Dec 2006	7	24	17
Jan 2007	2	27	9
Feb 2007	4	24	12
Mar 2007	1	24	6
Apr 2007	5	12	6
May 2007	11	11	5
Jun 2007	11	7	5
Jul 2007	9	7	4
Aug 2007	7	8	6
Sep 2007	4	6	4
Oct 2007	6	7	4
Nov 2007	7	6	2
Dec 2007	4	5	5
Jan 2008	5	12	4
Feb 2008	9	7	5
Mar 2008	15	11	6
Apr 2008	9	12	10
May 2008	16	14	7
Jun 2008	7	11	9
Jul 2008	27	8	9
Aug 2008	51	5	0
Sep 2008	53	4	2
Oct 2008	42	4	4
Nov 2008	18	0	1
Dec 2008	3	2	1
Jan 2009	2	5	4
Feb 2009	7	3	0
Mar 2009	36	5	3
Apr 2009	10	15	10
May 2009	7	5	1
Jun 2009	6	4	6
Jul 2009	7	5	6
Aug 2009	8	2	4
Sep 2009	14	4	2
Oct 2009	37	9	4
Nov 2009	14	4	5
Dec 2009	13	3	12
Jan 2010	8	2	1
Feb 2010	3	6	4
Mar 2010	6	5	5
Apr 2010	8	3	2
May 2010	4	0	2
Jun 2010	24	3	2
Jul 2010	8	2	3
Aug 2010	1	3	5
Sep 2010	4	3	1
Oct 2010	5	1	0
Nov 2010	3	3	3
Dec 2010	3	2	2
Jan 2011	4	4	3
Feb 2011	4	5	4
Mar 2011	9	8	5
Apr 2011	8	7	4
May 2011	6	2	2
Jun 2011	7	1	2
Jul 2011	9	6	2
Aug 2011	9	5	5
Sep 2011	7	4	4
Oct 2011	1	1	0
Nov 2011	6	3	5
Dec 2011	3	8	5
Jan 2012	10	5	4
Feb 2012	5	4	5
Mar 2012	7	8	3
Apr 2012	1	3	2
May 2012	9	11	9
Jun 2012	8	7	3
Jul 2012	7	12	8
Aug 2012	10	7	6
Sep 2012	14	10	12
Oct 2012	6	9	12
Nov 2012	8	7	1
Dec 2012	4	9	9
Jan 2013	15	6	3
Feb 2013	8	8	5
Mar 2013	6	3	2
Apr 2013	4	4	4
May 2013	14	9	10
Jun 2013	6	3	1
Jul 2013	14	2	4
Aug 2013	4	2	0
Sep 2013	12	5	5
Oct 2013	13	5	4
Nov 2013	11	5	3
Dec 2013	16	4	4
Jan 2014	22	11	2
Feb 2014	6	2	4
Mar 2014	15	9	5
Apr 2014	9	3	5
May 2014	11	19	12
Jun 2014	6	8	4
Jul 2014	21	12	2
Aug 2014	4	5	3
Sep 2014	5	0	0
Oct 2014	5	7	3
Nov 2014	1	4	5
Dec 2014	2	3	3
Jan 2015	9	4	2
Feb 2015	2	0	3
Mar 2015	12	10	2
Apr 2015	10	1	2
May 2015	2	3	1
Jun 2015	1	3	1
Jul 2015	7	9	1
Aug 2015	0	0	1
Sep 2015	14	1	3
Oct 2015	3	0	0
Nov 2015	2	3	2
Dec 2015	2	4	3
Jan 2016	4	0	0
Feb 2016	0	0	2
Mar 2016	2	1	4
Apr 2016	2	1	5
May 2016	9	3	3
Jun 2016	5	5	6
Jul 2016	5	7	5
Aug 2016	9	3	2
Sep 2016	8	1	1
Oct 2016	15	6	7
Nov 2016	14	3	3
Dec 2016	9	3	1
Jan 2017	8	4	1
Feb 2017	1	0	0
Mar 2017	1	6	5
Apr 2017	2	9	2
May 2017	1	7	1
Jun 2017	5	12	1
Jul 2017	11	11	3
Aug 2017	15	15	1
Sep 2017	15	15	4
Oct 2017	14	14	3
Nov 2017	14	14	1
Dec 2017	8	8	1
Jan 2018	11	11	0
Feb 2018	10	10	4
Mar 2018	14	12	3
Apr 2018	12	12	7
May 2018	15	15	7
Jun 2018	21	19	4
Jul 2018	15	13	6
Aug 2018	14	12	3
Sep 2018	14	14	1
Oct 2018	12	12	2
Nov 2018	14	12	1
Dec 2018	10	10	0
Jan 2019	12	11	3
Feb 2019	7	7	2
Mar 2019	6	6	2
Apr 2019	10	10	7
May 2019	9	9	4
Jun 2019	3	3	1
Jul 2019	11	11	6
Aug 2019	4	4	23
Sep 2019	2	2	2
Oct 2019	8	8	2
Nov 2019	5	6	2
Dec 2019	11	11	5
Jan 2020	8	8	4
Feb 2020	3	3	5
Mar 2020	4	4	6
Apr 2020	5	5	2
May 2020	10	10	3
Jun 2020	20	20	13
Jul 2020	8	8	0
Aug 2020	2	2	3
Sep 2020	17	17	3
Oct 2020	7	7	3
Nov 2020	6	6	2
Dec 2020	7	7	1
Jan 2021	6	3	3
Feb 2021	4	4	5
Mar 2021	5	3	4
Apr 2021	2	1	3
May 2021	7	7	4
Jun 2021	3	3	2
Jul 2021	3	3	0
Aug 2021	4	4	3
Sep 2021	3	3	3
Oct 2021	12	11	19
Nov 2021	5	5	12
Dec 2021	8	6	4
Jan 2022	10	11	11
Feb 2022	16	10	0
Mar 2022	12	12	8
Apr 2022	11	11	3
May 2022	25	25	12
Jun 2022	19	19	4
Jul 2022	13	13	1
Aug 2022	28	28	2
Sep 2022	15	15	8
Oct 2022	23	23	6
Nov 2022	8	8	4
Dec 2022	7	5	3
Jan 2023	2	2	2
Feb 2023	32	31	5
Mar 2023	21	21	2
Apr 2023	5	3	3
May 2023	4	4	6
Jun 2023	4	4	2
Jul 2023	5	5	7
Aug 2023	3	3	4
Sep 2023	2	2	3
Oct 2023	5	5	2
Nov 2023	15	15	2
Dec 2023	24	0	0
Jan 2024	20	0	0
Feb 2024	9	1	1
Mar 2024	2	0	0
Total	2486	2630	1218

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