Reactive arthritis or chronic infectious arthritis?
- Correspondence to:
Professor J Sibilia, Service de Rhumatologie, Hôpital de Hautepierre, 1 avenue Moliére, 67098 Strasbourg, Cedex, France;
- Accepted 4 March 2002
Microbes reach the synovial cavity either directly during bacteraemia or by transport within lymphoid cells or monocytes. This may stimulate the immune system excessively, triggering arthritis. Some forms of ReA correspond to slow infectious arthritis due to the persistence of microbes and some to an infection triggered arthritis linked to an extra-articular site of infection.
- IFN, interferon
- IL, interleukin
- LFA, leucocyte function associated antigen
- LPS, lipopolysaccharide
- MOMP, major outer membrane protein
- Osp, outer surface protein
- ReA, reactive arthritis
- RT-PCR, reverse transcriptase-polymerase chain reaction
- TNF tumour necrosis factor